Ueber Benzisothiazol

Hippokrates Ueber die Krankheiten III

irrelevant. Chemistry and the relations between science, technology, and industry are well surveyed by Crosland and Cardwell respectively. Forbes's essay on mathematical cosmography is not a comprehensive account but the story (albeit interesting) of a few German cartographers. Compared with other recent collections of essays in the history of science, this volume parades no party line: witness...

Ueber Das Verschwinden Der Θ-functionen

Ueber Die Fortpflanzung Ebener Luftwellen Von Endlicher Schwingungsweite

[Aus dem achten Bande der Abhandlungen der Königlichen Gesellschaft der Wissenschaften zu Göttingen. 1860.]

Ueber Die Fläche Vom Kleinsten Inhalt Bei Gegebener Begrenzung

Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors.

A number of 1,2-benzisothiazol-3-one derivatives were prepared through structural modification of the original compound from high-throughput screening. Some analogues (e.g., 6b, 6r, 6s and 6w) were identified as novel and potent caspase inhibitors with IC50 of nanomolar. Structure-activity relationship (SAR) studies for caspase-3 inhibition were evaluated in vitro. Molecular modeling studies pr...